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KMID : 0385020030190030153
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Korean Journal of Laboratory Animal Science
2003 Volume.19 No. 3 p.153 ~ p.160
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Skin Irritation and Sensitization Studies on a Transdermal Patch Composed of Physostigmine and Procyclidine for the Prophylaxis of Organophosphate Poisoning
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Lee Jong-Sung
Kim Yun-Jung
Park Cheol-Beom
Park Jong-Il
Cho Young
Seo Won-Jun
Kang Jong-Koo
Kim Yun-Bae
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Abstract
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The skin irritating and sensitizing potentials of a novel combinational transdermal patch, composed of physostigmine plus procyclidine as main active drugs, for organophosphate poisoning were investigated in rabbits and guinea pigs, respectively. In primary skin irritation test, rabbits were dermally attached with the active patch containing 1.5% physostigmine, 6% procyclidine and 0.5% hydrocortisone or with a placebo patch for 24 hrs. The patches did not induce any adverse reactions such as erythema and edema on both intact and abraded skin sites. So, the active patch was classified as a practically non-irritating material based on the score 0 of primary irritation index. In Buehler test, guinea pigs were sensitized by 6-hr attachment with the active or placebo patches every week for 3 weeks, and challenged 2 weeks later. The patches did not induce any allergic reactions, in contrast to a severe erythema, edema and pigmentation in positive control (0.1% 1-chloro-2,4-dinitrobenzene). Therefore, the active patch was graded as a weak material from 0 in both sensitization score and rate. Taken together, it is suggested that the combinational patch do not cause contact irritation and sensitization following single or repeated application.
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KEYWORD
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Combinational transdermal patch, Physostigmine, Procyclidine, Organophosphate poisoning, Skin irritation, Skin sensitization
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